Dr Mani-Babu graduated in Medicine from University College London Medical School in 2005, along with a First Class Honours Degree in Physiology. He completed the London Sport and Exercise Medicine (SEM) registrar training programme, including rotation through the Dance Injury Clinic at the Royal National Orthopaedic Hospital and became a Consultant in August 2013. He has also completed a Postgraduate Diploma in Medical Ultrasound.He has a variety of clinical and leadership experience within the NHS, Private Sector, Ministry of Defence and Elite Sport. He is a Fellow of the Royal College of Physicians (UK), Fellow of the Faculty of SEM and was appointed Honorary Secretary for the Faculty of SEM in 2018. 

Dr Mani-Babu is SEM Consultant in the SEM service at Barts Health NHS Trust in London. Previously, he has also worked for many years at the Defence Medical Rehabilitation Centre Headley Court, where he was lead consultant in the Centre for Spinal and Upper Quadrant Rehabilitation, Lead for Trainee Education and Consultant in the Centre for Lower Limbs Rehabilitation. 

His roles in sport have included medical team leader at Olympic and Paralympic Games (2012 London), Lead UK team doctor at The Invictus Games (2017 Toronto), National Classifier for the British Athletics Parallel Success Programme and Medical Officer in professional football with Brentford FC and Fulham FC. He has also worked in a variety of other sports including boxing, judo, basketball, marathon/athletics events and rugby.

Dr Mani-Babu is a strong advocate for a team-based approach to managing medical and musculoskeletal conditions not only for elite athletes but also for all individuals who would like to be physically active.